Kwame Opoku is a Ghanaian footballer who plays as a forward for USM Alger.
Opoku began his career at Division One League side Nkoranza Warriors, before signing for Asante Kotoko. In 2020, Asante Kotoko announced that they had signed him from Nkoranza-based club Nkoranza Warriors on a three-year contract. He scored a brace to earn a win against Liberty Professionals at the Accra Sports stadium on 11 January 2021.
On March 16, 2021, Opoku signed a four and half years contract with USM Alger for 350,000 euro. On May 8, 2021, Kwame played his new team’s debut in the League Cup in Algiers Derby and scored a goal in the match that ended in 2–0 victory, which occurred on his 22nd birthday
Opoku debuted for the Ghana national team in a 1–1 2021 Africa Cup of Nations Qualification tie with South Africa on 25 March 2021.
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